Retatrutide is a 39
amino acid single peptide with triple agonist activity at the glucagon
receptor (GCGR), glucosedependent insulinotropic polypeptide receptor
(GIPR), and glucagon-like peptide-1 receptor (GLP-1R). The backbone is
conjugated to a C20 fatty diacid moiety at position 17.
Retatrutide has a Glucose-dependent insulinotropic polypeptide (GIP)
peptide backbone, which then contains three non-coded amino acids. Aib2
(α-amino isobutyric acid) residues at positions 2 and 20 provide
stability against Dipeptidyl Peptidase 4 (DPP4) cleavage and contribute
to GIP activity. αMeL13 (α-methyl-L-leucine)at position 20 also
contributes to GIP and glucagon activity.
Retatrutide can be used for the research of obesity obesity, diabetes, and fatty liver disease. It is a works in three ways: stimulating insulin release, suppressing appetite, and promoting fat breakdown.